MedChem Study guides, Class notes & Summaries

Quiz 5 Medchem Drug Information Questions with complete solution

dactinomycin Drug type: Antitumor antibiotic; streptomyces parvulius; cyclic bis-depsipeptide attached to phenoxazine core MoA: Bind to DNA to inhibit DNa transcription, replication; p-benzoquinoneimine reduction by NADPH/CYP450 reductase --> hydroxy free radicals to break single stranded DNA Indications: Wilm's Tumor, Ewing's Sarcoma, Solid Malignancies Stats: IV dosing, Large Vd, minimal metabolism SEs: Toxic reactions, extravasation danger mitomycin C Drug type: Antitumor antib...

dactinomycin Drug type: Antitumor antibiotic; streptomyces parvulius; cyclic bis-depsipeptide attached to phenoxazine core MoA: Bind to DNA to inhibit DNa transcription, replication; p-benzoquinoneimine reduction by NADPH/CYP450 reductase --> hydroxy free radicals to break single stranded DNA Indications: Wilm's Tumor, Ewing's Sarcoma, Solid Malignancies Stats: IV dosing, Large Vd, minimal metabolism SEs: Toxic reactions, extravasation danger mitomycin C Drug type: Antitumor antib...

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