Doxorubicin Study guides, Class notes & Summaries

Doxorubicin Cardiotoxic TISSUE VESICANT Baseline MUGA and total dose (CONCERN at 550 mg/m2) URINE=RED IF EXTRAVASATION OCCURS= cool/ice + Totect Idamycin Cardiotoxic (cardiomyopathy) Bleomycin AVOID oxygen supplementation Methotrexate Leukovorin decreases cytotoxicity Pemetrexed Vitamin B12 & folic acid supplements to decrease toxicity Fludarabine Immunosuppression Thioguanine Bone Marrow Suppression Stomatitis/Mucositis 5-FU *Stomati...

Neoadjuvant therapy does not increase survival when compared to adjuvant therapy. It only changes the timing of treatment and can change surgical options if the tumor is shrunk enough. If this occurs, the patient may only require a lumpectomy plus radiation therapy instead of needing a mastectomy - Correct answer-Main benefit of neoadjuvant chemotherapy (breast cancer patient) A comprehensive geriatric assessment (CGA) is a multidisciplinary evaluation to assess life expectancy and risk of...

acetoHEXAMIDE/acetaZOLAMIDE correct answers acetoHEXAMIDE/acetaZOLAMIDE ALPRAZolam/LORazepam correct answers ALPRAZolam/LORazepam aMILoride/amLODIPine correct answers aMILoride/amLODIPine azaCITIDine/azaTHIOprine correct answers azaCITIDine/azaTHIOprine buPROPion/busPIRone correct answers buPROPion/busPIRone CARBOplatin/CISplatin correct answers CARBOplatin/CISplatin CeleXA/CeleBREX correct answers CeleXA/CeleBREX chlorproMAZINE/chlorproPAMIDE correct answers chlorproMAZINE/...

Resources LESSON 1: Cell cycle g1- increase in size s- dna replicated g2- cell enlarge and ready to divide m phase- 2 hours mitosis 4 stages, prophase, metaphase, anaphase, telophase -chemo targets certain points in the process apoptosis programmed cell death hematopoiesis formation of blood cells & how cells differentiate -myeloid: pre cells mature into RBCs, platelets and WBCs -lymphoid: pre cells- mature into WBCS Principles of Biotherapy: p51-95 immunol...

Dilated Cardiomyopathy: most common cause is ____. Others? - correct answer alcohol; may also be idiopathic, myocarditis, or drugs (doxorubicin) -- 1 in 3 cases of heart failure are caused by dilated cardiomyopathy What PE and EKG changes are seen with dilated cardiomyopathy? - correct answer PE: S3, JVD, crackles - possible mitral regurg EKG: nonspecific ST and T wave changes, LBBB Hypertrophic cardiomyopathy: is due to hypertrophy of the _____. PE reveals mitral regurgitation, a ____hea...

acetoHEXAMIDE/acetaZOLAMIDE - Answer-acetoHEXAMIDE/acetaZOLAMIDE ALPRAZolam/LORazepam - Answer-ALPRAZolam/LORazepam aMILoride/amLODIPine - Answer-aMILoride/amLODIPine azaCITIDine/azaTHIOprine - Answer-azaCITIDine/azaTHIOprine buPROPion/busPIRone - Answer-buPROPion/busPIRone CARBOplatin/CISplatin - Answer-CARBOplatin/CISplatin CeleXA/CeleBREX - Answer-CeleXA/CeleBREX chlorproMAZINE/chlorproPAMIDE - Answer-chlorproMAZINE/chlorproPAMIDE cloNIDine/klonoPIN - Answer-cloNIDine/klonoPIN CYCLOs...

USMLE STEP1 UWORLD NOTES- CVS Doxorubicin(anthracycline) mechanism of causing HF ? ANSWER IS - generate Fee radical, Early> sarcomere swelling. Late> "myofibril dropout" . cause Biventricular CHF and is cumulative toxicity What causes cellular swelling post MI ischemia ? ANSWER IS - Accumulation of Na and Ca in the cell due to pump failure percentage of libman-sacks of all SLE pts? ANSWER IS - 25%. vegis on both side of the valve after how many seconds of complete myocyte ischemi...

ONS CHEMO/BIO Exam With 100% Correct Answers 2023 Aklylating Agents -Cyclophosphamide -Cisplatin -Carboplatin -Oxaliplatin Cyclophosphamide (Cytoxan) Alkylating agent (cytotoxic antineoplastic) Kills rapidly growing cells by interrupting DNA/RNA synthesis Can cause bone marrow suppression, N/V, acute hemorrhagic cystitis*, alopecia Aggressive hydration pre and post infusion Cisplatin Vesicant Severe n/v Renal failure (hydration and electrolyte replacement) Ototoxicity,...

Emergency Medicine EOR Exam Verified Questions And Answers 2023 Dilated Cardiomyopathy: most common cause is ____. Others? alcohol; may also be idiopathic, myocarditis, or drugs (doxorubicin) -- 1 in 3 cases of heart failure are caused by dilated cardiomyopathy What PE and EKG changes are seen with dilated cardiomyopathy? PE: S3, JVD, crackles - possible mitral regurg EKG: nonspecific ST and T wave changes, LBBB Hypertrophic cardiomyopathy: is due to hypertrophy of the _____. PE reveals ...

Neoadjuvant therapy does not increase survival when compared to adjuvant therapy. It only changes the timing of treatment and can change surgical options if the tumor is shrunk enough. If this occurs, the patient may only require a lumpectomy plus radiation therapy instead of needing a mastectomy Main benefit of neoadjuvant chemotherapy (breast cancer patient) A comprehensive geriatric assessment (CGA) is a multidisciplinary evaluation to assess life expectancy and risk of morbidity and ...