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NRNP 6566 final prep 6-12
NRNP 6566 final prep 6-12 
Normal pH 
7.35-7.45 
 
<7.35 Acid 
>7.45 alkalosis 
respiratory aklalosis 
pH> 7.45, PaC02 low, HC03 low 
respiratory acidosis 
pH < 7.35 
PaCO2 > 45 
Hc03 normal 22-26 
Metabolic alkalosis 
pH > 7.45 
HCO3 > 26 
PaC02 45-35 
normal oxygen levle 
80-100 
mild hypoxemia 
60-80 
moderate hypoxemia 
40-60 
severe hypoxemia 
<40 
A-a gradiatian calculation is a calculation of what? 
level of hypoxia 
PA02-Pa02 
A-a gradiant varies with age, calcula...
- Exam (elaborations)
- • 9 pages •
NRNP 6566 final prep 6-12 
Normal pH 
7.35-7.45 
 
<7.35 Acid 
>7.45 alkalosis 
respiratory aklalosis 
pH> 7.45, PaC02 low, HC03 low 
respiratory acidosis 
pH < 7.35 
PaCO2 > 45 
Hc03 normal 22-26 
Metabolic alkalosis 
pH > 7.45 
HCO3 > 26 
PaC02 45-35 
normal oxygen levle 
80-100 
mild hypoxemia 
60-80 
moderate hypoxemia 
40-60 
severe hypoxemia 
<40 
A-a gradiatian calculation is a calculation of what? 
level of hypoxia 
PA02-Pa02 
A-a gradiant varies with age, calcula...
NRNP 6566 Mid-term Study Guide Week
NRNP 6566 
Mid-term Study Guide Week 1 to 5 
Week 1 
1. Describe the cytochrome P450 system. Describe how inducers and inhibitors affect the cytochrome system and how that affects the half-life of medications. 
Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and br...
- Exam (elaborations)
- • 16 pages •
NRNP 6566 
Mid-term Study Guide Week 1 to 5 
Week 1 
1. Describe the cytochrome P450 system. Describe how inducers and inhibitors affect the cytochrome system and how that affects the half-life of medications. 
Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and br...
NRNP 6566 Knowledge Check Week 3
NRNP 6566 Knowledge Check Week 3 
 
Amiodarone has possible complex interactions with multiple medications. It has an effect on warfarin metabolism. Amiodarone is a potent inhibitor of cytochrome P450 enzymes and inhibition of these enzymes will cause an increased plasma concentration and decreased clearance; thereby increasing the prothrombin time and INR placing the patient at increased risk for bleeding complications. Hence, when given 
together, warfarin dose should be decreased and frequent...
- Exam (elaborations)
- • 7 pages •
NRNP 6566 Knowledge Check Week 3 
 
Amiodarone has possible complex interactions with multiple medications. It has an effect on warfarin metabolism. Amiodarone is a potent inhibitor of cytochrome P450 enzymes and inhibition of these enzymes will cause an increased plasma concentration and decreased clearance; thereby increasing the prothrombin time and INR placing the patient at increased risk for bleeding complications. Hence, when given 
together, warfarin dose should be decreased and frequent...
NRNP 6566 Week 5 Knowledge Check
NRNP 6566 Week 5 Knowledge Check 
 
QUESTION 1 
1.	A 54-year women is 3 days post abdominal surgery for removal of a cancerous mass in her abdomen. She develops acute shortness of breath associated with tachycardia and hypotension. CT Scan of the chest is positive for multiple small pulmonary embolism. What medication and dosing would you order initially to treat the pulmonary embolism? 
 
This patient should be given fondaparinuc (Arixtra) subcutaneously. Dosing is weight- based: 
1.	5 mg SQ on...
- Exam (elaborations)
- • 4 pages •
NRNP 6566 Week 5 Knowledge Check 
 
QUESTION 1 
1.	A 54-year women is 3 days post abdominal surgery for removal of a cancerous mass in her abdomen. She develops acute shortness of breath associated with tachycardia and hypotension. CT Scan of the chest is positive for multiple small pulmonary embolism. What medication and dosing would you order initially to treat the pulmonary embolism? 
 
This patient should be given fondaparinuc (Arixtra) subcutaneously. Dosing is weight- based: 
1.	5 mg SQ on...
NRNP 6566 WK 10 Knowledge Check
NRNP 6566 WK 10 Knowledge Check 
 
 
 
 
A 57 year old female is admitted to the oncology unit for chemotherapy related to her to acute leukemia. Her initial dose of chemo was 2 days ago. While rounding today, the patients tells the NP that she feels so weak. The NP notes her heart rate is 44 today (down from 68 2 days ago). She has had less than 100 cc of urine out over the last 24 hours. 
 
Labs from this morning include: 
 
LAB DATA: 
-Sodium 131 
-Potassium 7.8 
-Chloride 105 
-Bicarbonate ...
- Exam (elaborations)
- • 8 pages •
NRNP 6566 WK 10 Knowledge Check 
 
 
 
 
A 57 year old female is admitted to the oncology unit for chemotherapy related to her to acute leukemia. Her initial dose of chemo was 2 days ago. While rounding today, the patients tells the NP that she feels so weak. The NP notes her heart rate is 44 today (down from 68 2 days ago). She has had less than 100 cc of urine out over the last 24 hours. 
 
Labs from this morning include: 
 
LAB DATA: 
-Sodium 131 
-Potassium 7.8 
-Chloride 105 
-Bicarbonate ...
NRNP 6566 MidtermStudy Guide
NRNP 6566 MidtermStudy Guide 
NRNP 6566 
Mid-term Study Guide Week 1 to 5 Week 1 
1. Describe the cytochrome P450 system. Describe how inducers and inhibitors affect the cytochrome system and how that affects the half-life of medications. 
Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as ...
- Exam (elaborations)
- • 16 pages •
NRNP 6566 MidtermStudy Guide 
NRNP 6566 
Mid-term Study Guide Week 1 to 5 Week 1 
1. Describe the cytochrome P450 system. Describe how inducers and inhibitors affect the cytochrome system and how that affects the half-life of medications. 
Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as ...
NRNP 6566 MidtermStudy Guide
NRNP 6566 MidtermStudy Guide 
NRNP 6566 
Mid-term Study Guide Week 1 to 5 Week 1 
1. Describe the cytochrome P450 system. Describe how inducers and inhibitors affect the cytochrome system and how that affects the half-life of medications. 
Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as ...
- Exam (elaborations)
- • 16 pages •
NRNP 6566 MidtermStudy Guide 
NRNP 6566 
Mid-term Study Guide Week 1 to 5 Week 1 
1. Describe the cytochrome P450 system. Describe how inducers and inhibitors affect the cytochrome system and how that affects the half-life of medications. 
Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as ...